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American Society for Microbiology, Journal of Clinical Microbiology, 2(47), p. 466-468, 2009

DOI: 10.1128/jcm.00892-08

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In Vivo and In Vitro Alterations in Influenza A/H3N2 Virus M2 and Hemagglutinin Genes: Effect of Passage in MDCK-SIAT1 Cells and Conventional MDCK Cells

Journal article published in 2008 by D. Li, R. Saito, Y. Suzuki, I. Sato, H. Zaraket ORCID, C. Dapat, I. M. Caperig-Dapat, H. Suzuki
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.