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Rockefeller University Press, Journal of Cell Biology, 7(206), p. 819-821, 2014

DOI: 10.1083/jcb.201408115

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A sharp end to sugary Wingless travels

Journal article published in 2014 by Ilia A. Droujinine, Dong Yan, Norbert Perrimon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp.