Links
Tools
Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor
Journal article published in 2011 by
Neil S. Keddie,
Yulin Ye,
Tashfeen Aslam,
Tomas Luyten,
Davide Bello,
Clive Garnham,
Geert Bultynck 
,
Antony Galione,
Stuart J. Conway
,
Antony Galione,
Stuart J. Conway
Abstract
The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.