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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(51), p. 4489-4491, 2007

DOI: 10.1128/aac.00687-07

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Novel Drug Resistance Pattern Associated with the Mutations K70G and M184V in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Journal article published in 2007 by D. Bradshaw ORCID, S. Malik, C. Booth, M. Van Houtte, T. Pattery, A. Waters, J. Ainsworth, A. M. Geretti
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

ABSTRACT We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.