Dissemin is shutting down on January 1st, 2025

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Elsevier, DNA Repair, (19), p. 182-189, 2014

DOI: 10.1016/j.dnarep.2014.03.012

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The contribution of dormant origins to genome stability: From cell biology to human genetics

Journal article published in 2014 by Robert C. Alver, J. Julian Blow, Gaganmeet Singh Chadha, J. Julian Blow ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins. © 2014 The Authors.