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Public Library of Science, PLoS ONE, 5(4), p. e5730, 2009

DOI: 10.1371/journal.pone.0005730

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Prion Strain Discrimination Based on Rapid In Vivo Amplification and Analysis by the Cell Panel Assay

Journal article published in 2009 by Yervand Eduard Karapetyan, Paula Saá ORCID, Sukhvir Paul Mahal, Gian Franco Sferrazza, Alexandra Sherman, Nicole Salès, Charles Weissmann, Corinne Ida Lasmézas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mice the four prion strains examined are rapidly and faithfully amplified and can subsequently be discriminated by a cell-based procedure, the Cell Panel Assay.