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BioMed Central, BMC Infectious Diseases, 1(2)

DOI: 10.1186/1471-2334-2-17

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Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C

Journal article published in 2002 by Raffaele Bruno ORCID, Paolo Sacchi, Massimo Puoti, Valentina Ciappina, Cristina Zocchetti, Enrico Brunetti, Elena Maffezzini, Anna Capelli, Savino Fa A. Patruno, Antonello Malfitano, Gaetano Filice
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART. The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. Methods We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA