American Physiological Society, Physiology, 4(12), p. 171-177
DOI: 10.1152/physiologyonline.1997.12.4.171
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The architecture of the cellular network forming the myocardium is an important determinant of the characteristics of impulse propagation. This article describes an experimental approach permitting the systematic study of this structure-function relationship, which is based on optical micromapping of electrical activity in cardiac cell cultures with a defined two-dimensional geometry.