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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(58), p. 602-605, 2014

DOI: 10.1128/aac.02591-12

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Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria

Journal article published in 2013 by Fatima El-Assaad, Valery Combes, Georges Emile Raymond Grau ORCID, Ronan Jambou
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro ; in combination with artesunate in vivo , confers partial protection against CM; and prolongs survival.