Published in

American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(58), p. 574-576, 2014

DOI: 10.1128/aac.01462-13

Links

Tools

Export citation

Search in Google Scholar

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

Journal article published in 2013 by Shashank Gupta, Keira A. Cohen, Kathryn Winglee ORCID, Mamoudou Maiga, Bassirou Diarra, William R. Bishai
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis . We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.