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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (9), p. 1630-1636, 2013

DOI: 10.3762/bjoc.9.186

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Anodic coupling of carboxylic acids to electron-rich double bonds: A surprising non-Kolbe pathway to lactones

Journal article published in 2013 by Robert J. Perkins, Hai-Chao Xu ORCID, John M. Campbell, Kevin D. Moeller
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Carboxylic acids have been electro-oxidatively coupled to electron-rich olefins to form lactones. Kolbe decarboxylation does not appear to be a significant competing pathway. Experimental results indicate that oxidation occurs at the olefin and that the reaction proceeds through a radical cation intermediate.