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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (9), p. 1643-1651, 2013

DOI: 10.3762/bjoc.9.188

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New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei

Journal article published in 2013 by Annamaria Sinisi, Barbara Calcinai, Carlo Cerrano, Henny A. Dien, Angela Zampella ORCID, Claudio D’Amore, Barbara Renga, Stefano Fiorucci, Orazio Taglialatela-Scafati
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chemical analysis of the organic extract of Theonella swinhoei yielded two new tridecadepsipeptides of the theonellapeptolide family, namely sulfinyltheonellapeptolide, characterized by a methylsulfinylacetyl group at the N-terminus, and theonellapeptolide If, the first member of this class of compounds to show four valine residues. The structures of the compounds, isolated along with the known theonellapeptolide Id, were determined by extensive 2D NMR and MS/MS analyses followed by application of Marfey’s method. The isolated peptides exhibited moderate antiproliferative activity against HepG2 cells, a hepatic carcinoma cell line.