Published in
American Society of Hematology, Blood, 25(127), p. 3270-3280, 2016
DOI: 10.1182/blood-2015-05-644476
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- ORCID
- American Society of Hematology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Programming of donor T cells using allogeneic δ-like ligand 4–positive dendritic cells to reduce GVHD in mice
Journal article published in 2016 by
Kazuhiro Mochizuki,
Lijun Meng,
Izumi Mochizuki,
Qing Tong,
Shan He,
Yongnian Liu,
Janaki Purushe,
Henry Fung,
M. Raza Zaidi 
,
Yanyun Zhang,
Ran Reshef,
Bruce R. Blazar,
Hideo Yagita,
Shin Mineishi,
Yi Zhang
,
Yanyun Zhang,
Ran Reshef,
Bruce R. Blazar,
Hideo Yagita,
Shin Mineishi,
Yi Zhang
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Abstract
Key Points Establishing a novel Dll4hiDC-based programming approach that produces alloreactive T cells able to eliminate leukemic cells without GVHD. Dll4 induction of T-cell IFN-γ limits the expansion of Dll4hiDC-induced T cells in GVHD target tissues and development of GVHD.