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Oxford University Press, The Journal of Infectious Diseases, 5(210), p. 728-735, 2014

DOI: 10.1093/infdis/jiu155

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HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

Journal article published in 2014 by Nancy M. Archin, Rosalie Bateson, Manoj K. Tripathy, Amanda M. Crooks, Kuo-Hsiung Yang, Noelle P. Dahl, Mary F. Kearney, Elizabeth M. Anderson, John M. Coffin, Matthew C. Strain, Douglas D. Richman, Kevin R. Robertson, Angela D. Kashuba, Ronald J. Bosch, Daria J. Hazuda and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human immunodeficiency virus (HIV)–positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not been directly measured, to our knowledge.