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Public Library of Science, PLoS ONE, 11(4), p. e7856, 2009

DOI: 10.1371/journal.pone.0007856

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Correlating Global Gene Regulation to Angiogenesis in the Developing Chick Extra-Embryonic Vascular System

Journal article published in 2009 by Sophie Javerzat, Mélanie Franco ORCID, John Herbert, Natalia Platonova, Anne-Lise Peille, Véronique Pantesco, John De Vos ORCID, Said Assou, Roy Bicknell, Andreas Bikfalvi, Martin Hagedorn
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis. METHOLOGY/PRINCIPAL FINDINGS: We accessed global gene regulation throughout maturation of the chick chorio-allantoic membrane (CAM), a highly vascularized tissue, using pan genomic microarrays. Seven percent of analyzed genes showed a significant change in expression (>2-fold, FDR