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American Chemical Society, Journal of Medicinal Chemistry, 10(50), p. 2450-2458, 2007

DOI: 10.1021/jm061173n

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Design and synthesis of novel quinolinone-3-aminoamides and their α-lipoic acid adducts as antioxidant and anti-inflammatory agents

Journal article published in 2007 by Anastasia Detsi, Dionysia Bouloumbasi, Kc Prousis ORCID, Maria Koufaki, Giorgos Athanasellis, Georgia Melagraki, Antreas Afantitis, Olga Igglessi-Markopoulou, Christos Kontogiorgis, Dj Hadjipavlou-Litina
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.