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Oxford University Press (OUP), Bioinformatics, 12(30), p. i319-i328

DOI: 10.1093/bioinformatics/btu291

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AlignGraph: algorithm for secondary de novo genome assembly guided by closely related references

Journal article published in 2014 by Ergude Bao, Tao Jiang, Thomas Girke
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: De novo assemblies of genomes remain one of the most challenging applications in next-generation sequencing. Usually, their results are incomplete and fragmented into hundreds of contigs. Repeats in genomes and sequencing errors are the main reasons for these complications. With the rapidly growing number of sequenced genomes, it is now feasible to improve assemblies by guiding them with genomes from related species.