Published in
American Society for Cell Biology, Molecular Biology of the Cell, 2(29), p. 154-165
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Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles
Journal article published in 2018 by
Elea Prezel,
Auréliane Elie,
Julie Delaroche 
,
Virginie Stoppin-Mellet,
Christophe Bosc,
Laurence Serre,
Anne Fourest-Lieuvin,
Annie Andrieux,
Marylin Vantard,
Isabelle Arnal
,
Virginie Stoppin-Mellet,
Christophe Bosc,
Laurence Serre,
Anne Fourest-Lieuvin,
Annie Andrieux,
Marylin Vantard,
Isabelle Arnal
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Abstract
Tau is a neuronal microtubule bundler that is known to stabilize microtubules by promoting their growth and inhibiting their shrinkage. This study reveals novel mechanisms by which tau is able to switch microtubule network organizations via the differential regulation of microtubule bundling and dynamics.