Published in
American Society for Cell Biology, Molecular Biology of the Cell, 2(29), p. 137-153
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DRC2/CCDC65 is a central hub for assembly of the nexin–dynein regulatory complex and other regulators of ciliary and flagellar motility
Journal article published in 2018 by
Raqual Bower,
Douglas Tritschler,
Kristyn VanderWaal Mills,
Thomas Heuser 
,
Daniela Nicastro,
Mary E. Porter
,
Daniela Nicastro,
Mary E. Porter
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Abstract
DRC2 is a subunit of the nexin–dynein regulatory complex linked to primary ciliary dyskinesia. Little is known about the impact of drc2 mutations on axoneme composition and structure. We used proteomic and structural approaches to reveal that DRC2 coassembles with DRC1 to attach the N-DRC to the A-tubule and mediate interactions with other regulatory structures.