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Taylor and Francis Group, Molecular && Cellular Oncology, 4(5), p. e1481813

DOI: 10.1080/23723556.2018.1481813

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex.

Journal article published in 2018 by Alba Maiques-Diaz, James T. Lynch, Gary J. Spencer, Tim C. P. Somervaille ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.