Radek Indra - Dissemin

All papers authored by Radek Indra

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2021 Helena Dračínská

, Radek Indra

, Sandra Jelínková, Věra Černá

, Volker Arlt

, Marie Stiborová

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes

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Kateřina Jáklová, Tereza Feglarová, Simona Rex

, Zbyněk Heger, Tomáš Eckschlager

, Jan Hraběta, Petr Hodek

, Matúš Kolárik, Radek Indra

Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib

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2020 Radek Indra

, Katarína Vavrová

, Petr Pompach, Zbyněk Heger, Petr Hodek

Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity

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Radek Indra

, Petr Pompach, Katarína Vavrová

, Kateřina Jáklová, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt

, Marie Stiborová

Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems

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2019 Mateja Sborchia, Eric G. De Prez, Marie-Hélène Antoine, Lucie Bienfait, Radek Indra

, Gabriel Valbuena, David H. Phillips, Joëlle L. Nortier, Marie Stiborová, Hector C. Keun, Volker M. Arlt

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

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Radek Indra

, Petr Pompach, Václav Martínek

, Paulína Takácsová, Katarína Vavrová

, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt

, Marie Stiborová

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation

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Radek Indra

, Tereza Černá, Zbyněk Heger, Jan Hraběta, Marek Wilhelm, Simona Dostálová, Alžběta Lengálová, Markéta Martínková

, Vojtěch Adam, Tomáš Eckschlager, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells

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Lindsay Reed, Radek Indra

, Iveta Mrizova, Michaela Moserova, Heinz H. Schmeiser, C. Roland Wolf, Colin J. Henderson, Marie Stiborova, David H. Phillips, Volker M. Arlt

Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

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2018 R. Indra

, T. Cerna, Z. Heger, V. Adam, S. Dostalova, T. Eckschlager, M. Stiborova

Apoferritine-encapsulated ellipticine – construction and properties

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Alexandra J. Willis, Radek Indra

, Laura E. Wohak, Osman Sozeri, Kerstin Feser, Iveta Mrizova, David H. Phillips, Marie Stiborova, Volker M. Arlt

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells

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Lindsay Reed, Iveta Mrizova, Frantisek Barta, Radek Indra

, Michaela Moserova, Klaus Kopka, Heinz H. Schmeiser, C. Roland Wolf, Colin J. Henderson, Marie Stiborova, David H. Phillips

, Volker M. Arlt

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

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This paper was not found in any repository; the policy of its publisher is unknown or unclear.

R. Indra

, P. Pompach, P. Takacsova, K. Vavrova, Z. Heger

, Adam, T. Eckschlager, K. Kopeckova, M. Stiborova

Oxidation of a tyrosine kinase inhibitor vandetanib by human cytochromes P450 and flavin monooxygenases in vitro and its effect of DNA adduct formation mediated by an anticancer drug ellipticine

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M. Sborchia, E. G. De Prez, L. Bienfait, R. Indra

, H. Dracinska, J. Nortier, M. Stiborova, H. Keun, V. M. Arlt

Toxicogenomics changes induced by the human carcinogen aristolochic acid I in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

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T. Cerna, J. Hrabeta, R. Indra

, Z. Heger

, Adam, T. Eckschlager, M. Stiborova

Doxorubicin and ellipticine loaded apoferritin and its effect on cancer and healthy cell lines

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Mattis Kolarik, Radek Indra

, Vojtech Adam, Zbynek Heger, Katerina Kopeckova, Volker M. Arlt, Marie Stiborova

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro

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K. Vavrova, R. Indra

, P. Pompach, Z. Heger

, Adam, T. Eckschlager, K. Kopeckova, M. Stiborova

A tyrosine kinase inhibitor lenvatinib is oxidized by human cytochromes P450 and aldehyde oxidase in vitro

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R. Indra

, M. Kolarik, M. Stiborova

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib affect oxidation of an anticancer drug ellipticine by cytochromes P450 but not by peroxidases

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M. Stiborova, R. Indra

, P. Hodek

, E. Frei, Martinek, H. Schmeiser, Arlt

A role of cytochrome b5 in CYP1A1-mediated oxidation of benzo[a]pyrene and other substrates

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R. Indra

, M. Wilhelm, T. Cerna, T. Eckschlager, S. Dostalova, Z. Heger

, Adam, M. Stiborova

Nanocarrier of apoferritin with encapsulated ellipticine - its construction and properties

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R. Indra

, M. Wilhelm, Z. Heger

, S. Dostalova, Adam, M. Stiborova

Construction of an apoferritin nanoparticle bearing ellipticine and a study of release of this drug from the nanocarrier

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All papers authored by Radek Indra