David Crich - Dissemin

All papers authored by David Crich

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2024 Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich

, Sven N. Hobbie

In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides

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Ruslans Muhamadejevs, Klara Haldimann, Marina Gysin, David Crich

, Kristaps Jaudzems

, Sven N. Hobbie

Experimental Determination of the pK_a Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing pK_a─Activity Relationships

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2023 Dmitrijs Lubriks

, Klara Haldimann, Fatmanur Kiliç, Maximilian Hartmann, Erik C. Böttger

, Sven N. Hobbie

, Edgars Suna

, David Crich

Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)‐Ia Resistance Determinant

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Santanu Jana

, Parasuraman Rajasekaran, Klara Haldimann, Andrea Vasella, Erik C. Böttger, Sven N. Hobbie

, David Crich

Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2

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2022 Michael G. Pirrone

, Chennaiah Ande

, Klara Haldimann, Sven N. Hobbie

, Andrea Vasella

, Erik C. Böttger

, David Crich

Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction

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Jonathan C. K. Quirke

, Girish C. Sati

, Amr Sonousi

, Marina Gysin

, Klara Haldimann, Erik C. Böttger, Andrea Vasella

, Sven N. Hobbie

, David Crich

Structure‐Activity Relationships for 5′′ Modifications of 4,5‐Aminoglycoside Antibiotics

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2021 Dimitrijs Lubriks, Rimants Zogota, Vikram A. Sarpe

, Takahiko Matsushita, Girish C. Sati

, Klara Haldimann, Marina Gysin, Erik C. Böttger, Andrea Vasella, Edgars Suna

, Sven N. Hobbie

, David Crich

Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5′′- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes

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Michael G. Pirrone

, Sven N. Hobbie

, Andrea Vasella, Erik C. Böttger, David Crich

Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity

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Yifei Wu, Scott D. Pegan

, David Crich

, Ellison Desrochers, Edward B. Starling, Madelyn C. Hansen

, Carson Booth, Lauren Nicole Mullininx, Lei Lou, Kuan Y. Chang

, Zhong-Ru Xie

Polyphenols as alternative treatments of COVID-19

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2020 Amr Sonousi, Jonanthan Quirke, Prabuddha Waduge, Tanja Janusic, Marina Gysin, Klara Haldimann, Sven N. Hobbie

, Su-Hua Sha, Shan Xu, Jochen Schacht, Christine S. Chow, Andrea Vasella, David Crich

, Chow Christine, Erik C. Bottger

An Advanced Apralog with Increased in‐vitro and in‐vivo Activity toward Gram‐negative Pathogens and Reduced ex‐vivo Cochleotoxicity

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Michael Gabriel Pirrone

, Marina Gysin, Klara Haldimann, Sven N. Hobbie

, Andrea Vasella, David Crich

Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site

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Sandeep Dhanju

, Kapil Upadhyaya, Christopher A. Rice

, Scott D. Pegan

, Joseph Media, Frederick A. Valeriote, David Crich

Synthesis, Cytotoxicity, and Genotoxicity of 10-Aza-9-oxakalkitoxin, an N,N,O-Trisubstituted Hydroxylamine Analog, or Hydroxalog, of a Marine Natural Product

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2019 Jonathan C. K. Quirke, Parasuraman Rajasekaran, Vikram A. Sarpe, Amr Sonousi, Ivan Osinnii, Marina Gysin, Klara Haldimann, Qiao-Jun Fang, Dimitri Shcherbakov, Sven N. Hobbie

, Su-Hua Sha, Jochen Schacht, Andrea Vasella, Erik C. Böttger, David Crich

Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant

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Girish C. Sati, Vikram A. Sarpe

, Takayuki Furukawa, Sujit Mondal, Matilde Mantovani, Sven N. Hobbie

, Andrea Vasella, Erik C. Böttger, David Crich

Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity

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Takahiko Matsushita, Girish C. Sati, Nuwan Kondasinghe, Michael G. Pirrone, Takayuki Kato, Prabuddha Waduge, Harshitha Santhosh Kumar, Adrian Cortes Sanchon, Malgorzata Dobosz-Bartoszek, Dimitri Shcherbakov, Mario Juhas, Sven N. Hobbie

, Thomas Schrepfer, Christine S. Chow, Yury S. Polikanov and 4 other authors

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

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Vikram A. Sarpe, Michael G. Pirrone, Klara Haldimann, Sven N. Hobbie

, Andrea Vasella, David Crich

Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity

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2017 Appi Reddy Mandhapati, Guanyu Yang, Takayuki Kato, Dimitri Shcherbakov, Sven N. Hobbie

, Andrea Vasella, Erik C. Böttger, David Crich

Structure-Based Design and Synthesis of Apramycin–Paromomycin Analogues: Importance of the Configuration at the 6′-Position and Differences between the 6′-Amino and Hydroxy Series

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Girish C. Sati, Dimitri Shcherbakov, Sven N. Hobbie

, Andrea Vasella, Erik C. Böttger, David Crich

N6′, N6′′′, and O4′ Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity

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All papers authored by David Crich