Royal Society of Chemistry, Organic and Biomolecular Chemistry, 37(15), p. 7736-7742
DOI: 10.1039/c7ob02033c
Full text: Unavailable
An efficient, metal-free synthesis of unusual α-keto γ-amino esters from α-amino acids is achieved by a radical scission–oxidation–addition of silyloxy acrylates procedure, where no purification of the reaction intermediates is needed. The process allows the synthesis of α,γ-peptides.