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Ferrata Storti Foundation, Haematologica, 3(94), p. 364-371
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A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia
Journal article published in 2009 by
J. A. Hernandez,
José Ángel Hernández,
Ana Eugenia Rodríguez,
Marcos González,
Rocío Benito 
,
Celia Fontanillo,
Virgilio Sandoval,
Mercedes Romero,
Guillermo Martín-Núñez,
Alfonso García de Coca,
Rosa Fisac,
Josefina Galende,
Isabel Recio,
Francisco Ortuño,
Juan Luis García
and other authors.
,
Celia Fontanillo,
Virgilio Sandoval,
Mercedes Romero,
Guillermo Martín-Núñez,
Alfonso García de Coca,
Rosa Fisac,
Josefina Galende,
Isabel Recio,
Francisco Ortuño,
Juan Luis García
and other authors.
This paper is made freely available by the publisher.
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Abstract
In B-cell chronic lymphoid leukemia, patients with 13q14 deletion generally have a favorable outcome. The findings of this study suggest that the number of malignant cells with 13q14 deletion may influence the outcome of patients with this cytogenetic abnormality as a single chromosomal aberration. A high number of malignant cells carrying the 13q14 deletion, as assessed by FISH, appears to be associated with short overall survival and time to progression.