The future quasi-biennial oscillation (QBO) in ozone in the equatorial stratosphere is examined by analyzing transient climate simulations due to increasing greenhouse gases (GHGs) and decreasing ozone-depleting substances under the auspices of the Chemistry–Climate Model Initiative. The future (1960–2100) and historical (1979–2010) simulations are conducted with the Meteorological Research Institute Earth System Model. Three climate periods, 1960–85 (past), 1990–2020 (present), and 2040–70 (future) are selected, corresponding to the periods before, during, and after ozone depletion. The future ozone QBO is characterized by increases in amplitude by 15%–30% at 5–10 hPa and decreases by 20%–30% at 40 hPa, compared with the past and present climates; the future and present ozone QBOs increase in amplitude by up to 60% at 70 hPa, compared with the past climate. The increased amplitude at 5–10 hPa suggests that the temperature-dependent photochemistry plays an important role in the enhanced future ozone QBO. The weakening of vertical shear in the zonal wind QBO is responsible for the decreased amplitude at 40 hPa in the future ozone QBO. An interesting finding is that the weakened zonal wind QBO in the lowermost tropical stratosphere is accompanied by amplified QBOs in ozone, vertical velocity, and temperature. Further study is needed to elucidate the causality of amplification about the ozone and temperature QBOs under climate change in conditions of zonal wind QBO weakening.