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Frontiers Media, Frontiers in Neuroscience, (9)

DOI: 10.3389/fnins.2015.00123

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Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Journal article published in 2015 by Norman R. Saunders, Katarzyna M. Dziegielewska, Kjeld Møllgård, Mark D. Habgood, Matthew J. Wakefield ORCID, Helen Lindsay, Nathalie Stratzielle, Jean-Francois Ghersi-Egea, Shane A. Liddelow
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The transcriptome of embryonic and adult rat lateral ventricular choroid plexus, using a combination of RNA-Sequencing and microarray data, was analyzed by functional groups of influx transporters, particularly solute carrier (SLC) transporters. RNA-Seq was performed at embryonic day (E) 15 and adult with additional data obtained at intermediate ages from microarray analysis. The largest represented functional group in the embryo was amino acid transporters (twelve) with expression levels 2–98 times greater than in the adult. In contrast, in the adult only six amino acid transporters were up-regulated compared to the embryo and at more modest enrichment levels (