Published in
Taylor and Francis Group, OncoImmunology, 9(1), p. 1612-1613
DOI: 10.4161/onci.21480
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- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Next-generationsequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
Journal article published in 2012 by
Giuliana Amaddeo,
Cécile Guichard,
Sandrine Imbeaud 
,
Jessica Zucman-Rossi
,
Jessica Zucman-Rossi
This paper is made freely available by the publisher.
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Abstract
Genetic studies were performed in a French series of hepatocellular carcinomas. New oncogenes (NFE2L2) and tumor suppressor genes (IRF2, ARID1A and RPS6K3) were found to be recurrently altered. Moreover, a genotoxic signature was identified, raising the possible implication of a genotoxic exposure in the etiology of HCC, which remains to be characterized.