In this paper, we consider a three-machine makespan minimization permutation flow shop scheduling problem with shortening job processing times. Shortening job processing times means that its processing time is a nonincreasing function of its execution start time. Optimal solutions are obtained for some special cases. For the general case, several dominance properties and two lower bounds are developed to construct a branch-and-bound (B&B) algorithm. Furthermore, we propose a heuristic algorithm to overcome the inefficiency of the branch-and-bound algorithm.