Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound
Journal article published in 2018 by
Shadi Sedghi Masoud 
,
Yudai Yamaoki ,
Yue Ma,
Adrien Marchand ,
Fernaldo Richtia Winnerdy,
Valérie Gabelica ,
Anh Tuân Phan ,
Masato Katahira ,
Kazuo Nagasawa
,
Yudai Yamaoki ,
Yue Ma,
Adrien Marchand ,
Fernaldo Richtia Winnerdy,
Valérie Gabelica ,
Anh Tuân Phan ,
Masato Katahira ,
Kazuo Nagasawa
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Abstract
The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites.