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Frontiers Media, Frontiers in Endocrinology, (4)

DOI: 10.3389/fendo.2013.00094

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UGT2B17 Genotype and the Pharmacokinetic Serum Profile of Testosterone during Substitution Therapy with Testosterone Undecanoate. A Retrospective Experience from 207 Men with Hypogonadism

Journal article published in 2013 by Anne Kirstine Bang, Niels Jørgensen, Ewa Rajpert-De Meyts, Ewa Rajpert De Meyts, Anders Juul ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Testosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate (TU) substitution therapy.