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Oxford University Press (OUP), Briefings in Functional Genomics, 5(13), p. 371-377

DOI: 10.1093/bfgp/elu022

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Using population isolates in genetic association studies

Journal article published in 2014 by Konstantinos Hatzikotoulas, Arthur Gilly ORCID, Eleftheria Zeggini ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates. We cite successful examples of using population isolates in association studies and outline potential ways forward.