Royal Society of Chemistry, Chemical Communications, 89(52), p. 13086-13089, 2016
DOI: 10.1039/c6cc06451e
Full text: Unavailable
PUBLISHED ; Export Date: 8 December 2016 ; Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs. ; SFI: PI 2013 13/IA/1865