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National Academy of Sciences, Proceedings of the National Academy of Sciences, 35(113), p. 9904-9909, 2016

DOI: 10.1073/pnas.1525066113

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Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation

Journal article published in 2016 by Arnau Busquets-Garcia, Maria Gomis-González, Raj Kamal Srivastava, Laura Cutando, Antonio Ortega-Alvaro, Sabine Ruehle, Floortje Remmers ORCID, Laura Bindila, Luigi Bellocchio, Giovanni Marsicano, Beat Lutz, Rafael Maldonado, Andrés Ozaita ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance This study discloses specific central and peripheral mechanisms involving cannabinoid type-1 (CB1) receptors in impairing the effect of acute stress on the consolidation of nonemotional memory in rodents. Both hippocampal and peripheral CB1 receptors in dopamine β-hydroxylase–expressing cells (i.e., in adrenergic/noradrenergic cells) are identified as necessary and sufficient for stress-induced memory impairment. Our study provides the foundation for the development of novel potential approaches to tackle cognitive alterations in stress-related disorders.