Dissemin is shutting down on January 1st, 2025

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Optica, Biomedical Optics Express, 2(8), p. 943, 2017

DOI: 10.1364/boe.8.000943

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Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Journal article published in 2017 by M. (Manhong) Wu, Geert Springeling, T. (Tirza) Springeling, M. (Matija) Lovrak, F. (Frits) Mastik, S. (Sophinese) Iskander-Rizk, T. (Tianshi) Wang, Heleen M. M. van Beusekom, H. M. M. (Heleen) van Beusekom, A. F. W. van der Steen, A. F. W. (Ton) van der Steen, G. (Gijs) van Soest, Gijs Van Soest ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.