Inhibition of miR-181a-5p promotes Wnt/β-catenin signaling. a Luciferase activity assay performed in HEK293 cells co-transfected with a microRNA inhibitor targeting miR-181a-5p and luciferase reporter plasmids driven by either WT or MUT 3′-UTR of β-catenin and TCF4 that was devoid of miR-181a-5p binding activity. b The protein levels of β-catenin and TCF4 as determined by Western blot analysis in HCT116 and SW480 cells transfected with miR-181a-5p inhibitor or miR-control inhibitor. c TOP/FOP luciferase activity in HCT116 and SW480 cells transfected with a microRNA inhibitor targeting miR-181a-5p or a control microRNA inhibitor. *P