CRNDE overexpression and miR-181a-5p knockdown promote CRC cell chemoresistance. a MTT cell proliferation assay performed in HCT116 and SW480 cells transfected with plasmids overexpressing CRNDE or a control vector and treated with the indicated concentrations of 5-Fu. b MTT cell proliferation assay performed in HCT116 and SW480 cells transfected with miR-181a-5p inhibitor or miR-control inhibitor and treated with the indicated concentrations of 5-Fu. c MTT cell proliferation assay performed in HCT116 and SW480 cells transfected with plasmids overexpressing CRNDE or a control vector and treated with the indicated concentrations of Oxa. d MTT cell proliferation assay performed in HCT116 and SW480 cells transfected with miR-181a-5p inhibitor or miR-control inhibitor and treated with the indicated concentrations of Oxa. *P