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Elsevier, Physica A: Statistical Mechanics and its Applications, (483), p. 456-461

DOI: 10.1016/j.physa.2017.04.144

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Evolution of the Ubiquitin-Activating Enzyme Uba1 (E1)

Journal article published in 2017 by Douglas C. Allan, J. C. Phillips
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences. ; Comment: 12 pages, 6 figures