American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(48), p. 1895-1899, 2004
DOI: 10.1128/aac.48.5.1895-1899.2004
Full text: Download
ABSTRACT WM5, a 6-aminoquinolone derivative, binds with high affinity to the bulge of the trans -activation-responsive region (TAR), whereas it displays low binding affinity for the loop and stem regions of TAR and for random RNA and DNA sequences. Furthermore, WM5 disrupts the natural protein-nucleic acid complex with a 50% inhibitory concentration in the low micromolar range in both in vitro and in vivo assays.