Links

Tools

Export citation

Search in Google Scholar

Genome Sequence of Aedes aegypti, a Major Arbovirus Vector

Journal article published in 2007 by Evgeny Zbobnov, Vishvanath Nene, Jennifer R. Wortman, Daniel Lawson ORCID, Brian Haas, Zhijian Jake Tu, Chinnappa Kodira, Zj Tu, Brendan Loftus, Zy Xi, Karyn Megy, Manfred Grabherr, Qh Ren, Em M. Zdobnov, Nf F. Lobo and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Question mark in circle
Preprint: policy unknown
Question mark in circle
Postprint: policy unknown
Question mark in circle
Published version: policy unknown

Abstract

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at ~1.38 Gbp is ~5-fold larger in size than the genome of the malaria vector, Anopheles gambiae. Nearly 50% of the Aedes aegypti genome consists of transposable elements. These contribute to a ~4-6 fold increase in average gene length and the size of intergenic regions relative to Anopheles gambiae and Drosophila melanogaster. Nevertheless, chromosomal synteny is generally maintained between all three insects although conservation of orthologous gene order is higher (~2-fold) between the mosquito species than between either of them and fruit fly. Three methods have provided transcriptional evidence for 80% of the 15,419 predicted protein coding genes in Aedes aegypti. An increase in genes encoding odorant binding, cytochrome P450 and cuticle domains relative to Anopheles gambiae suggests that members of these protein families underpin some of the biological differences between them.