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Oxford University Press, Briefings in Functional Genomics and Proteomics, 5(8), p. 345-352

DOI: 10.1093/bfgp/elp020

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Finding common susceptibility variants for complex disease: past, present and future

Journal article published in 2009 by Kalliope Panoutsopoulou, Eleftheria Zeggini ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The identification of complex disease susceptibility loci has been accelerated considerably by advances in high-throughput genotyping technologies, improved insight into correlation patterns of common variants and the availability of large-scale sample sets. Linkage scans and small-scale candidate gene studies have now given way to genome-wide association scans. In this review, we summarize insights gained from the past, highlight practical issues relating to the design and analysis of current state-of-the-art GWA studies and look into future trends in the field of human complex trait genetics.