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American Society for Microbiology, Journal of Virology, 19(86), p. 10873-10879, 2012

DOI: 10.1128/jvi.01506-12

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Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

Journal article published in 2012 by Jelke J. Fros ORCID, Natalia E. Domeradzka, Jim Baggen ORCID, Corinne Geertsema, Jacky Flipse, Just M. Vlak, Gorben P. Pijlman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.