Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Stahl, Eli A.; Raychaudhuri, Soumya; Remmers, Elaine F.; Ea, Stahl; Xie, Gang; Thomson, Brian P.; Eyre, Stephen; Kurreeman, Fina A. S.; BIRAC_Consortium,; Li, Yonghong; Bart A. Crusius, J.; Amos, Christopher I.; Ef, Remmers; Zhernakova, Alexandra; Ardlie, Kristin G.; Hinks, Anne; Barton, Anne; Bowes, John; Guiducci, Candace; Brouwer, Elisabeth; Burtt, Noel P.; Chen, Robert; Bakker, P. I. de; Catanese, Joseph Jj; de Bakker, Paul I. W.; Alfredsson, Lars; Coblyn, Jonathan; Coenen, Marieke Jh H.; Costenbader, Karen H.; Criswell, Lindsey A.; Crusius, Jb Bart A.; Cui, Jing; De Jager, Phillip L.; Jager, P. L.; Ding, Bo; Emery, Paul; Flynn, Edward; Bp, Thomson; Harrison, Pille; Hocking, Lynne J.; Huizinga, Tom W. J.; Kastner, Daniel L.; Ke, Xiayi; Lee, Annette T.; van der Helm-Van Mil, Annette H. M.; Liu, Xiangdong; Helm-Van Mil, A. H. van der; van der Horst-Bruinsma, Irene E.; Martin, Paul; Morgan, Ann W.; van der Schoot, Ce Ellen; Padyukov, Leonid; van Riel, Piet Lcm C. M.; Posthumus, Marcel D.; Radstake, Timothy Rdj D. J.; Fa, Kurreeman; Reid, David M.; Horst-Bruinsma, I. E. van der; Seielstad, Mark; Seldin, Michael F.; Ellen van der Schoot, C.; Shadick, Nancy A.; de Vries, Niek; Steer, Sophia; Tak, Paul Pp; Thomson, Wendy; Schoot, C. E. van der; Riel, P. L. C. M. van; Weinblatt, Michael E.; Wilson, Anthony G.; Wolbink, Gert Jan; Wordsworth, Paul; Paul Wordsworth, B.; Wordsworth, Bp Paul; YEAR_Consortium,; Wijmenga, Cisca; Karlson, Elizabeth W.; Toes, Rene E. M.; Vries, N. de; Begovich, Ann B.; Worthington, Jane; Siminovitch, Katherine A.; Gregersen, Peter K.; Klareskog, Lars; Plenge, Robert M.; Rm, Plenge

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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Journal article published in 2010 by Eli A. Stahl, Soumya Raychaudhuri, Elaine F. Remmers, Stahl Ea, Gang Xie, Brian P. Thomson, Stephen Eyre

, Fina A. S. Kurreeman, BIRAC_Consortium, Yonghong Li, J. Bart A. Crusius, Christopher I. Amos, Remmers Ef, Alexandra Zhernakova, Kristin G. Ardlie and other authors.

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Abstract

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.

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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Abstract