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American Chemical Society, Journal of the American Chemical Society, 14(131), p. 5203-5207, 2009

DOI: 10.1021/ja8087339

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One-Electron Reduction Potential of the Neutral Guanyl Radical in the GC Base Pair of Duplex DNA

Journal article published in 2009 by Sujata Ss Shinde, Andrej Maroz, Michael P. Hay ORCID, Robert F. Anderson
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The one-electron oxidation of guanine in the GC base pair of DNA has been investigated using pulse radiolysis combined with DFT calculations. Reaction of benzotriazinyl radicals with DNA results in the formation of the neutral guanyl radical and redox equilibria. The one-electron reduction potential, E(7), of the neutral guanyl radical in the GC base pair is determined for the first time as 1.22 +/- 0.02 V, from both absorption and kinetic data.