PURPOSE: To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1.5 T, quantitative CT, and PFTs. Whole-lung and lobar (129)Xe MR imaging parameters were obtained by using automated segmentation of multisection hyperpolarized (129)Xe MR ventilation images and hyperpolarized (129)Xe MR diffusion-weighted images after coregistration to CT scans. Whole-lung and lobar quantitative CT-derived metrics for emphysema and bronchial wall thickness were calculated. Pearson correlation coefficients were used to evaluate the relationship between imaging measures and PFT results. RESULTS: Percentage ventilated volume and average ADC at lobar (129)Xe MR imaging showed correlation with percentage emphysema at lobar quantitative CT (r = -0.32, P