Cyclotron and Linac technologies cover the vast majority of accelerator solutions applied to medicine. Cyclotrons with beams of H⁺/H⁻ around 20 MeV are found for radioisotope production and cyclotrons with beams up to 250 MeV are widely used for protontherapy. Linacs are present in every medium-sized hospital with electron beams up to 20 MeV for radiotherapy and radioimaging. They have also recently become available as commercial products for protontherapy. The coupling of these two strong technologies enables to expand the capabilities of cyclotrons by using linacs as boosters. This opens the way to innovative accelerator systems allowing both radioisotope production and ion beam therapy (cyclinacs), new treatment techniques (high energy proton therapy) and new imaging techniques (proton radiography). This paper provides an overview of the technical challenges linked to coupling cyclotrons to linacs and the various solutions at hand. ; SeriesInformation ; Proceedings of the 21st Int. Conf. on Cyclotrons and Their Applications, Cyclotrons2016, Zurich, Switzerland