Links

Tools

Export citation

Search in Google Scholar

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

Journal article published in 2016 by Wj J. Astle, Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Al L. Mann, Daniel Mead ORCID, Heleen Bouman, Fernando Riveros-Mckay, Myrto A. Kostadima, Jj J. Lambourne, Suthesh Sivapalaratnam, Kate Downes, Kousik Kundu, Lorenzo Bomba and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Question mark in circle
Preprint: policy unknown
Question mark in circle
Postprint: policy unknown
Question mark in circle
Published version: policy unknown

Abstract

Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell, white cell, and platelet properties in 173,480 European-ancestry participants. This effort yielded hundreds of low frequency (