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Nature Research, Nature, 7635(541), p. 81-86

DOI: 10.1038/nature20784

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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Journal article published in 2016 by Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, Wr Scott, Sonja Kunze, Pc Tsai, Js Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P