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Impact Journals, Oncotarget, 46(7), p. 74734-74746, 2016

DOI: 10.18632/oncotarget.12543

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HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Journal article published in 2016 by Helen Ross-Adams, Stephen Ball, Roslin Russell, Kate Lawrenson, Claire Wells, Silvia Halim, Siri H. Strand, Torben F. Ørntoft, Melissa Larson, Sebastian Armasu, Martin M. Mortensen, Charles E. Massie ORCID, Mohammad Asim, Kathryn Woodfine, Anne Y. Warren and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenetic silencing, and outline a mechanism by which common risk variants could effect functional changes that increase disease risk: functional assays suggest that HNF1B is a pro-differentiation factor that suppresses epithelial-to-mesenchymal transition (EMT) in unmethylated, healthy tissues. This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC. Epigenetic inactivation of HNF1B in ovarian cancer also associates with known risk SNPs, with a similar impact on EMT. This represents one of the first comprehensive studies into the pleiotropic role of a GWAS-associated transcription factor across distinct cancer types, and is the first to describe a conserved role for a multi-cancer genetic risk factor.