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Additional file 1: Figure S1. of Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Representative histology of a 103-week-old mouse (#1825) that developed poorly differentiated tumor in the prostate. CD45 stains for all leukocyte antigens in the infiltrates. Supplement Figure 2. Exogenous human IL-6 induces paracrine mouse IL-6 expression in two mouse prostate tumor cell lines, the TRAMP-C2 and MyC-Cap. Fifty nanogram per milliliter of human IL-6 was supplemented in the culture media. Cells were harvested at 24 and 48Â hr of culture. Relative mouse IL-6 expression was assessed by quantitative RT-PCR. Table S1. Function of the most significantly upregulated genes with more than log2 fold changes in the volcano plot. Table S2. Upregulated inflammation-associated genes in the prostate of pbIL-6 mice that are not highlighted on the volcano plot. Table S3. Upregulated oncogenic genes in the prostate of pbIL-6 mice that are not highlighted on the volcano plot. Table S4. Upregulated metabolism-associated genes in the prostate of pbIL-6 mice that are not highlighted on the volcano plot. Table S5. List of primers used for qRT-PCR. (PDF 329 kb)