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Lippincott, Williams & Wilkins, Therapeutic Drug Monitoring, 4(38), p. 525-533, 2016

DOI: 10.1097/ftd.0000000000000301

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Genetic predisposition to poor opioid response in preterm infants: Impact of KCNJ6 and COMT polymorphisms on pain relief after endotracheal intubation.

Journal article published in 2016 by Laure Elens ORCID, Norman Elisabeth, Matic Maja, Anders Rane, Vineta Fellman, Ron Hn N. van Schaik
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Single nucleotide polymorphisms (SNPs) in genes involved in pain control might predispose to exaggerated sensitivity or difference in opioid analgesic effect. The relevance of the KCNJ6 -1250G>A (rs6517442, c.-1787G>A) and the COMT c.472G>A (rs4680, ValMet) SNPs were studied in preterm infants needing intubation and randomized to a premedication strategy including remifentanil (n=17) or morphine (n=17).